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HomeProduct name listSodium thioglycolate

Sodium thioglycolate

Synonym(s):Mercaptoacetic acid sodium salt;Sodium thioglycolate;Sodium thioglycollate;Thioglycolic acid sodium salt

  • CAS NO.:367-51-1
  • Empirical Formula: C2H5NaO2S
  • Molecular Weight: 116.11
  • MDL number: MFCD00043386
  • EINECS: 206-696-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:07:02
Sodium thioglycolate Structural

What is Sodium thioglycolate?

Chemical properties

White solid

The Uses of Sodium thioglycolate

Sodium thioglycolate has been used:

  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

The Uses of Sodium thioglycolate

dipilatory, irritant, chelating agent

The Uses of Sodium thioglycolate

In cold-waving of hair; as depilatory; in bacteriology for the preparation of thioglycolate media; as analytical reagent, see Thioglycolic Acid.

What are the applications of Application

Sodium thioglycolate is a disulfide reducing agent

Definition

The sodium salt of thioglycolic acid.

General Description

White powder with a slight odor. Used in cold-waving of hair and as a dipilatory.

Air & Water Reactions

Hygroscopic. Discolors on exposure to air. Water soluble.

Reactivity Profile

Sodium thioglycolate is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.

Hazard

Yields toxic hydrogen sulfide on decompo- sition, may be toxic by skin absorption.

Fire Hazard

Flash point data for Sodium thioglycolate are not available. Sodium thioglycolate is probably combustible.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS.

Purification Methods

It crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]

Properties of Sodium thioglycolate

Melting point: >300 °C (lit.)
vapor pressure  <0.1 hPa (25 °C)
storage temp.  -20°C
solubility  609.1g/l
form  solid
pka 3.82[at 20 ℃]
color  White powder
Odor Stench odour
PH Range 6.5 - 8 at 114 g/l at 25 °C
PH 6.7 (100g/l, H2O, 20℃)
Water Solubility  soluble
Sensitive  Air Sensitive & Hygroscopic
Merck  14,8692
BRN  4569109
Exposure limits ACGIH: TWA 1 ppm (Skin)
CAS DataBase Reference 367-51-1(CAS DataBase Reference)
EPA Substance Registry System Sodium thioglycolate (367-51-1)

Safety information for Sodium thioglycolate

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H290:Corrosive to Metals
H301:Acute toxicity,oral
H312:Acute toxicity,dermal
H317:Sensitisation, Skin
Precautionary Statement Codes P234:Keep only in original container.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Sodium thioglycolate

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