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HomeProduct name listMethyl thioglycolate

Methyl thioglycolate

Synonym(s):Methyl mercaptoacetate

  • CAS NO.:2365-48-2
  • Empirical Formula: C3H6O2S
  • Molecular Weight: 106.14
  • MDL number: MFCD00004873
  • EINECS: 219-121-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
Methyl thioglycolate Structural

What is Methyl thioglycolate?

Chemical properties

CLEAR COLOURLESS LIQUID

The Uses of Methyl thioglycolate

Methyl Thioglycolate is an derivative of Thioglycolic Acid (T350760), an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are oft en used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its inf luence on neocarzinostatin activation and expression of DNA damage.

The Uses of Methyl thioglycolate

Methyl thioglycolate was used in the preparation of 3-carbomethoxy-4- oxotetrahydrothiopyran, 2- and 4-carbomethoxy-3-oxotetrahydrothiophene. It is used to prepare methyl thioglycolate and aminoethanethiol conjugated gold nanorods.

What are the applications of Application

Methyl thioglycolate is A thiol organocatalyst

What are the applications of Application

Methyl thioglycolate is a chemical compound that is used in the pharmaceutical industry as an intermediate. It has been used to synthesize anti-inflammatory drugs, such as aspirin and ibuprofen, and also for the treatment of autoimmune diseases. Methyl thioglycolate binds to amino acids on the surface of bacteria, which prevents them from functioning properly. This binding causes the cells to stop growing and die.

Definition

Methyl thioglycolate are widely used in free-radical photoinitiated polymerization reactions. In particular, the use of methyl thioglycolate (MTG), CH3OC(O)CH2SH, results in greater photopolymerization reaction rates, attributed to a weakening of the sulfur–hydrogen bond by hydrogen bonding of the thiol group. MTG constitutes the smaller exponent of the series of CH3OC(O)(CH2)nSH compounds, reported as intermediated in the organic sulfur cycle in marine environments, produced by marine phytoplankton.

Production Methods

Adding thioglycollic acid with purity of between 70.0 and 96.0 percent and methanol with purity of between 95.0 and 99.9 percent into a reaction device according to the molar ratio of 1:1.3-4.0; subsequently, adding an activating agent into the reaction device, stirring and heating for reaction; and after the reaction is finished, carrying out separatory distillation on reaction products to obtain the methyl thioglycolate. The activating agent is a p-toluenesulfonic acid methanol solution with a mass concentration of between 20 and 30 percent, and the use amount is 0.5 to 1.0 percent of the total mass of relative input materials.

General Description

Methyl thioglycolate reacts with nonprotein component of the antitumor antibiotic neocarzinostatin to form 1:1 adduct. It reacts with isothiocyanate to form Rhodanine.

Properties of Methyl thioglycolate

Melting point: -24 °C
Boiling point: 42-43 °C/10 mmHg (lit.)
Density  1.187 g/mL at 25 °C (lit.)
refractive index  n20/D 1.466(lit.)
Flash point: 86 °F
storage temp.  Store below +30°C.
solubility  40g/l
pka 8.04±0.10(Predicted)
form  Liquid
color  Clear colorless
Water Solubility  40 g/L (20 ºC)
Sensitive  Air Sensitive
BRN  506259
CAS DataBase Reference 2365-48-2(CAS DataBase Reference)
NIST Chemistry Reference Acetic acid, mercapto-, methyl ester(2365-48-2)
EPA Substance Registry System Acetic acid, mercapto-, methyl ester (2365-48-2)

Safety information for Methyl thioglycolate

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H226:Flammable liquids
H301:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Methyl thioglycolate

InChIKey MKIJJIMOAABWGF-UHFFFAOYSA-N

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