Abiraterone acetate
Synonym(s):17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate;Abiraterone acetate;CB 7598
- CAS NO.:154229-18-2
- Empirical Formula: C26H33NO2
- Molecular Weight: 391.55
- MDL number: MFCD00934213
- EINECS: 620-314-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-18 08:51:57
What is Abiraterone acetate?
Description
In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).
The Uses of Abiraterone acetate
Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
What are the applications of Application
Abiraterone Acetate is a steroidal inhibitor of CYP17A1 in androgen biosynthesis
Properties of Abiraterone acetate
Melting point: | 127-130°C |
Boiling point: | 506.7±50.0 °C(Predicted) |
Density | 1.14±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly) |
form | powder |
color | white to beige |
Safety information for Abiraterone acetate
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H360:Reproductive toxicity H372:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Abiraterone acetate
Abamectin manufacturer
Jigs Chemical ltd
SGMR PHARMACEUTICALS PVT LTD
Dr. Reddy's Laboratories Ltd
Bulat Pharmaceutical Pvt Ltd
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