4-MALEIMIDOBUTYRIC ACID

Synonym(s):γ-Maleimidobutyric acid;4-Maleimidobutanoic acid;N-(3-Carboxypropyl)maleimide;N-Maleoyl-4-aminobutyric acid;N-Maleoyl-GABA

CAS NO.：57078-98-5
Empirical Formula: C8H9NO4
Molecular Weight: 183.16
MDL number: MFCD00043139
EINECS: 611-461-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 10:28:25

What is 4-MALEIMIDOBUTYRIC ACID?

Description

4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical properties

White Solid

The Uses of 4-MALEIMIDOBUTYRIC ACID

4-Maleimidobutyric Acid is a short crosslinking reagent.

The Uses of 4-MALEIMIDOBUTYRIC ACID

A short crosslinking reagent
Modification reagent for thiol groups in proteins
Maleimide Derivatives
MTS & Sulfhydryl Active Reagents

What are the applications of Application

4-Maleimidobutyric Acid is A bifunctional crosslinking agent

Properties of 4-MALEIMIDOBUTYRIC ACID

Melting point:	95-98 °C
Boiling point:	400.1±28.0 °C(Predicted)
Density	1.395±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form	Solid
pka	4.59±0.10(Predicted)
color	White to Pale Yellow
BRN	1455876
CAS DataBase Reference	57078-98-5(CAS DataBase Reference)

Safety information for 4-MALEIMIDOBUTYRIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.