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HomeProduct name list4-MALEIMIDOBUTYRIC ACID

4-MALEIMIDOBUTYRIC ACID

Synonym(s):γ-Maleimidobutyric acid;4-Maleimidobutanoic acid;N-(3-Carboxypropyl)maleimide;N-Maleoyl-4-aminobutyric acid;N-Maleoyl-GABA

  • CAS NO.:57078-98-5
  • Empirical Formula: C8H9NO4
  • Molecular Weight: 183.16
  • MDL number: MFCD00043139
  • EINECS: 611-461-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-25 10:28:25
4-MALEIMIDOBUTYRIC ACID Structural

What is 4-MALEIMIDOBUTYRIC ACID?

Description

4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical properties

White Solid

The Uses of 4-MALEIMIDOBUTYRIC ACID

4-Maleimidobutyric Acid is a short crosslinking reagent.

The Uses of 4-MALEIMIDOBUTYRIC ACID

  1. A short crosslinking reagent
  2. Modification reagent for thiol groups in proteins
  3. Maleimide Derivatives
  4. MTS & Sulfhydryl Active Reagents

What are the applications of Application

4-Maleimidobutyric Acid is A bifunctional crosslinking agent

Properties of 4-MALEIMIDOBUTYRIC ACID

Melting point: 95-98 °C
Boiling point: 400.1±28.0 °C(Predicted)
Density  1.395±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form  Solid
pka 4.59±0.10(Predicted)
color  White to Pale Yellow
BRN  1455876
CAS DataBase Reference 57078-98-5(CAS DataBase Reference)

Safety information for 4-MALEIMIDOBUTYRIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-MALEIMIDOBUTYRIC ACID

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