N-Ethylmaleimide
Synonym(s):NEM;N-Ethylmaleimide - CAS 128-53-0 - Calbiochem
- CAS NO.:128-53-0
- Empirical Formula: C6H7NO2
- Molecular Weight: 125.13
- MDL number: MFCD00005509
- EINECS: 204-892-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is N-Ethylmaleimide?
Chemical properties
White solid
The Uses of N-Ethylmaleimide
N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.
The Uses of N-Ethylmaleimide
Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
The Uses of N-Ethylmaleimide
In cancer research (possible antimitotic activity.)
What are the applications of Application
N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation
Definition
ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.
Hazard
Lachrymator when liquid, a strong irritant.
Biochem/physiol Actions
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Safety Profile
Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.
Properties of N-Ethylmaleimide
Melting point: | 43-46 °C(lit.) |
Boiling point: | 210 °C(lit.) |
Density | 1.2500 (rough estimate) |
refractive index | 1.4430 (estimate) |
Flash point: | 73 °C |
storage temp. | 2-8°C |
solubility | methanol: 1 M at 20 °C, clear, colorless |
form | Crystalline Powder |
pka | -2.18±0.20(Predicted) |
color | White to off-white |
Water Solubility | 1 g/L (20 ºC) |
Sensitive | Light Sensitive |
Merck | 14,3822 |
BRN | 112448 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate. |
CAS DataBase Reference | 128-53-0(CAS DataBase Reference) |
NIST Chemistry Reference | 1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0) |
EPA Substance Registry System | N-Ethylmaleimide (128-53-0) |
Safety information for N-Ethylmaleimide
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H300:Acute toxicity,oral H311:Acute toxicity,dermal H314:Skin corrosion/irritation H317:Sensitisation, Skin |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for N-Ethylmaleimide
InChIKey | HDFGOPSGAURCEO-UHFFFAOYSA-N |
Abamectin manufacturer
Pallav Chemicals And Solvents Pvt Ltd
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
N-Ethylmaleimide CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide ExiPlus CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide extrapure CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide CAS 128-53-0View Details
128-53-0 -
N-Ethylmaleimide CAS 128-53-0View Details
128-53-0