N-Succinimidyl 3-maleimidopropionate

Synonym(s):BMPS;N-Succinimidyl 3-maleimidopropionate;N-(3-Maleimidopropionyloxy)succinimide;N-Maleoyl-β-alanine N′-hydroxysuccinimide ester;N-(3-Maleimidopropionyloxy)succinimide

CAS NO.：55750-62-4
Empirical Formula: C11H10N2O6
Molecular Weight: 266.21
MDL number: MFCD00043141
EINECS: 627-755-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

N-Succinimidyl 3-maleimidopropionate Structural

What is N-Succinimidyl 3-maleimidopropionate?

Description

3-Maleimido-propionic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical properties

White to off-white solid

The Uses of N-Succinimidyl 3-maleimidopropionate

A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent, N-Succinimidyl 3-maleimidopropionate can also been used in immunodiagnostics.

The Uses of N-Succinimidyl 3-maleimidopropionate

3-Maleimidopropionic acid N-hydroxysuccinimide ester is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.

What are the applications of Application

3-Maleimidopropionic Acid N-Succinimidyl Ester is An amine- and sulfhydryl- reactive heterobifunctional crosslinking reagent, 6.9 angstrom spacer arm

Properties of N-Succinimidyl 3-maleimidopropionate

Melting point:	168-170 °C(lit.)
Boiling point:	448.8±47.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-2.39±0.20(Predicted)
color	White to Light Brown
Water Solubility	Insoluble in water.
Sensitive	Moisture Sensitive
BRN	1492578
InChI	InChI=1S/C11H10N2O6/c14-7-1-2-8(15)12(7)6-5-11(18)19-13-9(16)3-4-10(13)17/h1-2H,3-6H2
CAS DataBase Reference	55750-62-4(CAS DataBase Reference)

Safety information for N-Succinimidyl 3-maleimidopropionate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray.