N-Succinimidyl 3-maleimidopropionate
Synonym(s):BMPS;N-Succinimidyl 3-maleimidopropionate;N-(3-Maleimidopropionyloxy)succinimide;N-Maleoyl-β-alanine N′-hydroxysuccinimide ester;N-(3-Maleimidopropionyloxy)succinimide
- CAS NO.：55750-62-4
- Empirical Formula: C11H10N2O6
- Molecular Weight: 266.21
- MDL number: MFCD00043141
- EINECS: 627-755-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is N-Succinimidyl 3-maleimidopropionate?
Description
3-Maleimido-propionic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical properties
White to off-white solid
The Uses of N-Succinimidyl 3-maleimidopropionate
A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent, N-Succinimidyl 3-maleimidopropionate can also been used in immunodiagnostics.
The Uses of N-Succinimidyl 3-maleimidopropionate
3-Maleimidopropionic acid N-hydroxysuccinimide ester is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.
What are the applications of Application
3-Maleimidopropionic Acid N-Succinimidyl Ester is An amine- and sulfhydryl- reactive heterobifunctional crosslinking reagent, 6.9 angstrom spacer arm
Properties of N-Succinimidyl 3-maleimidopropionate
| Melting point: | 168-170 °C(lit.) |
| Boiling point: | 448.8±47.0 °C(Predicted) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -2.39±0.20(Predicted) |
| color | White to Light Brown |
| Water Solubility | Insoluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1492578 |
| InChI | InChI=1S/C11H10N2O6/c14-7-1-2-8(15)12(7)6-5-11(18)19-13-9(16)3-4-10(13)17/h1-2H,3-6H2 |
| CAS DataBase Reference | 55750-62-4(CAS DataBase Reference) |
Safety information for N-Succinimidyl 3-maleimidopropionate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. |
Computed Descriptors for N-Succinimidyl 3-maleimidopropionate
| InChIKey | JKHVDAUOODACDU-UHFFFAOYSA-N |
| SMILES | N1(CCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O |
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