2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
Synonym(s):(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;Flucyamide;N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide;SU 20
- CAS NO.：108605-62-5
- Empirical Formula: C12H9F3N2O2
- Molecular Weight: 270.21
- MDL number: MFCD00910058
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide?
Description
Teriflunomide (Aubagio®), also known as A77 1726, is an immunosupressant marketed by Sanofi for the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced B and T cell proliferation.
The Uses of 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.
Properties of 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
| Melting point: | 229-232°C |
| Boiling point: | 410.8±45.0 °C(Predicted) |
| Density | 1.424±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming). |
| form | neat |
| color | White |
Safety information for 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
Abamectin manufacturer
Honour Lab Limited
1Y
Phone:+919845977466
Whatsapp: +91-9845977466
product: Teriflunomide 108605-62-5 98%
Shilpa Medicare Limited (SML)
1Y
Phone:+91-9320649838
Whatsapp: +91-9320649838
product: 108605-62-5 99%
Megafine Pharma
1Y
Phone:+91-9867686666
Whatsapp: +91 9867686666
product: Teriflunomide 108605-62-5 99%
NATCO Pharma Limited
1Y
Phone:+91-9866005199
Whatsapp: +91 9866005199
product: 108605-62-5 Teriflunomide 98%
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