1-Adamantaneacetic acid

Synonym(s):1-Adamantylacetic acid

CAS NO.：4942-47-6
Empirical Formula: C12H18O2
Molecular Weight: 194.27
MDL number: MFCD00074728
EINECS: 225-585-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-14 19:04:07

What is 1-Adamantaneacetic acid?

Chemical properties

white to off-white crystalline powder or crystals

The Uses of 1-Adamantaneacetic acid

1-Adamantaneacetic acid was used as an acylating agent in determining pharmacological characteristics of ten new analogues of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) that were modified in the N-terminal part of the molecule.

What are the applications of Application

1-Adamantaneacetic acid is an acylating agent

Biochem/physiol Actions

1-Adamantaneacetic acid is an inhibitor of chorismate mutase-prephenate dehydrogenase (EC 1.3.1.12) from Escherichia coli K12 (strain JP 232).

Purification Methods

Dissolve the acid in hot NaOH, treat with charcoal, filter and acidify. Collect the solid, wash it with H2O, dry and recrystallise it from MeOH. [Stetter et al. Chem Ber 92 1629 1959.] The acid chloride [2094-72-6] has M 168.7, m 51-54o, and b 135-136o/1mm. LACHRYMATORY.

Properties of 1-Adamantaneacetic acid

Melting point:	134-137 °C (lit.)
Boiling point:	270.73°C (rough estimate)
Density	1.0086 (rough estimate)
refractive index	1.4949 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Solubility in Methanol - almost transparency
form	Crystalline Powder or Crystals
pka	5.00±0.10(Predicted)
color	White to off-white
BRN	641412
CAS DataBase Reference	4942-47-6(CAS DataBase Reference)
NIST Chemistry Reference	1-Adamantaneacetic acid(4942-47-6)

Safety information for 1-Adamantaneacetic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.