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HomeProduct name list(Z)-Guggulsterone

(Z)-Guggulsterone

  • CAS NO.:95975-55-6
  • Empirical Formula: C21H28O2
  • Molecular Weight: 312.45
  • MDL number: MFCD01310757
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-14 20:10:21
(Z)-Guggulsterone Structural

What is (Z)-Guggulsterone?

The Uses of (Z)-Guggulsterone

Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.

What are the applications of Application

Guggulsterone is a broad spectrum steroid receptor ligand

Definition

ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.

Biological Activity

Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).

Properties of (Z)-Guggulsterone

Boiling point: 463.3±45.0 °C(Predicted)
Density  1.10±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 5 mg/mL
form  powder
color  light yellow
CAS DataBase Reference 95975-55-6(CAS DataBase Reference)

Safety information for (Z)-Guggulsterone

Computed Descriptors for (Z)-Guggulsterone

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