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HomeProduct name listXL147

XL147

XL147 Structural

What is XL147?

Description

XL147 analog is an analog of XL147 .

The Uses of XL147

XL147 analogue is one of Pyrimidine derivatives as JAK-2 inhibitors in combination with other agents and their use in the treatment of diseases.

What are the applications of Application

XL-147 derivative 2 is an ATP-competetive class I PI3K inhibitor

Definition

ChEBI: XL147 is a sulfonamide that is the N-4-toluenesulfonyl (N-tosyl) derivative of N-(2,1,3-benzothiadiazol-5-yl)quinoxaline-2,3-diamine. A selective PI3K inhibitor used in cancer treatment. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a sulfonamide, a quinoxaline derivative, a benzothiadiazole and an aromatic amine.

Properties of XL147

Boiling point: 638.9±65.0 °C(Predicted)
Density  1.538
storage temp.  Store at -20°C
solubility  ≥22.45 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form  solid
pka 6.71±0.30(Predicted)
color  Light brown to brown

Safety information for XL147

Computed Descriptors for XL147

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