MK-4101
- CAS NO.:935273-79-3
- Empirical Formula: C24H24F5N5O
- Molecular Weight: 493.47
- MDL number: MFCD30343842
- Update Date: 2024-07-02 08:55:13
What is MK-4101?
Biological Activity
mk-4101 is a hedgehog (hh) signaling pathway inhibitor.abnormal activation of the hedgehog (hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma.
in vitro
mk-4101 was found to target the hh pathway in tumor cells, with the maximum inhibitory effect on gli1. mk-4101 could also induce the deregulation of cell cycle and block of dna replication in tumors. in addition, members of the igf and wnt signaling pathways were among the most highly deregulated genes by mk-4101, indicating that the interplay among hh, igf, and wnt was critical in hh-dependent tumorigenesis [1].
in vivo
in a previous study, using neonatally irradiated ptch1(+/-) mice as a model of hh-dependent tumors, the in vivo effects of mk-4101 was investigated for the treatment of medulloblastoma and basal cell carcinoma. results showed a potent antitumor activity of mk-4101, achieved by the inhibition of proliferation and induction of extensive apoptosis. moreover, beside antitumor activity on transplanted tumors, mk-4101 was found to be highly efficacious against primary medulloblastoma and basal cell carcinoma in the cerebellum and skin [1].
References
[1] filocamo g et al. mk-4101, a potent inhibitor of the hedgehog pathway, is highly active against medulloblastoma and basal cell carcinoma. mol cancer ther. 2016 jun;15(6):1177-89.
Properties of MK-4101
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | A crystalline solid |
color | White to off-white |
Safety information for MK-4101
Computed Descriptors for MK-4101
New Products
SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Azithromycin Imp D Azithromycin EP Impurity C Atracurium Besylate EP Impurity D Azithromycin EP Impurity B Azithromycin EP Impurity O Cetirizine Glycerol Ester Impurity HydrochlorideRelated products of tetrahydrofuran
You may like
-
Atracurium Besylate EP Impurity CView Details
86293-35-8 -
Atracurium Besylate EP Impurity DView Details
87046-72-8 -
Azithromycin EP Impurity BView Details
307974-61-4 -
Azithromycin EP Impurity CView Details
620169-47-3 -
Azithromycin EP Impurity OView Details
763924-54-5 -
Azithromycin Imp DView Details
612069-26-8 -
Ceftaroline fosamil Acetate HydrateView Details
400827-55-6 -
Cetirizine Glycerol Ester Impurity HydrochlorideView Details
1243652-36-9