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HomeProduct name listVatalanib Dihydrochloride

Vatalanib Dihydrochloride

Synonym(s):1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine dihydrochloride;N-(4-Chloroanilino)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride;

Vatalanib Dihydrochloride Structural

What is Vatalanib Dihydrochloride?

Description

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemical properties

White to Off-White Crystalline Powder

The Uses of Vatalanib Dihydrochloride

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

The Uses of Vatalanib Dihydrochloride

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

What are the applications of Application

Vatalanib Dihydrochloride is a potent inhibitor of EGFR- and RET-dependent tumor cell proliferation and survival

References

1) Wood?et al. (2000),?PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration;? Cancer Res.,?60?2178 2) Lin?et al. (2002),?The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment;? Cancer Res.,?62?5019

Properties of Vatalanib Dihydrochloride

Melting point: 268-2700C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
form  solid
color  White or off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference 212141-51-0

Safety information for Vatalanib Dihydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Vatalanib Dihydrochloride

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