TENOVIN-1
- CAS NO.:380315-80-0
- Empirical Formula: C20H23N3O2S
- Molecular Weight: 369.48
- MDL number: MFCD02914760
- EINECS: 200-256-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is TENOVIN-1?
Description
Tenovin-
The Uses of TENOVIN-1
Tenovin 1 is a sirtuin inhibitor.
What are the applications of Application
Tenovin-1 is an inhibitor of SIRT1 and SIRT2
Definition
ChEBI: N-[(4-acetamidoanilino)-sulfanylidenemethyl]-4-tert-butylbenzamide is a member of thioureas.
Biological Activity
p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21 CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro .
References
Lain et al. (2008), Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator; Cancer Cell, 13 454 Sonnemann et al. (2014), p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors; Br. J. Cancer 110 656 Nihal et al. (2014), SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis; Cell Cycle 13 632 Wilking et al. (2014), SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation; Arch. Biochem. Biophys. 563 94 Marx et al. (2018), The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line; New Drugs 36 396 Bang et al. (2019), Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes; Biomol. Ther. (Seoul) 27 283
Properties of TENOVIN-1
Melting point: | >180°C (Subl.) |
Density | 1.238±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in DMSO (10 mg/ml with warming) |
form | solid |
pka | 9.09±0.70(Predicted) |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for TENOVIN-1
Computed Descriptors for TENOVIN-1
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