4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
- CAS NO.:58131-57-0
- Empirical Formula: C11H13N5O4
- Molecular Weight: 279.25
- MDL number: MFCD01908645
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide?
Description
NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).
The Uses of 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
NSC-207895 is an anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2. It can also be used in pharmacological activity and therapeutic use of reviving antibiotics in relation to prepared efflux pump inhibitors that interact with AcrA, membrane fusion protein of AcrAB-TolC multidrug efflux pump.
What are the applications of Application
NSC-207895 is an anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2.
References
[1] hawes jj, nerva jd, reilly km. novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds. j biomol screen. 2008 sep;13(8):795-803.
[2] wang h, ma x, ren s, buolamwini jk, yan c. a small-molecule inhibitor of mdmx activates p53 and induces apoptosis. mol cancer ther. 2011 jan;10(1):69-79.
[3] kapitzky l, beltrao p, berens tj, gassner n, zhou c, wüster a, wu j, babu mm, elledge sj, toczyski d, lokey rs, krogan nj. cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. mol syst biol. 2010 dec 21;6:451.
Properties of 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
Boiling point: | 487.6±55.0 °C(Predicted) |
Density | 1.64 |
storage temp. | Store at -20°C |
solubility | Limited solubility |
form | Powder |
pka | 6.23±0.42(Predicted) |
color | Brown to reddish brown |
Safety information for 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%View Details
99903-60-3 -
88491-46-7 98%View Details
88491-46-7 -
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%View Details
25408-95-1 -
2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%View Details
1805639-70-6 -
1784294-80-9 98%View Details
1784294-80-9 -
Lithium ClavulanateView Details
61177-44-4