tasquinimod

CAS NO.：254964-60-8
Empirical Formula: C20H17F3N2O4
Molecular Weight: 406.36
MDL number: MFCD18251454
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is tasquinimod?

Description

Tasquinimod is an orally-active quinoline-3-carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases. Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer. While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.

The Uses of tasquinimod

Tasquinimod is an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.

storage

Store at -20°C

Properties of tasquinimod

Boiling point:	501.5±50.0 °C(Predicted)
Density	1.427±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	insoluble in H2O; ≥20.32 mg/mL in DMSO; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
form	solid
pka	4.50±1.00(Predicted)
color	White to light yellow

Safety information for tasquinimod

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.