GNE-9605
- CAS NO.：1536200-31-3
- Empirical Formula: C17H20ClF4N7O
- Molecular Weight: 449.83
- MDL number: MFCD28167997
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:16
What is GNE-9605?
Description
GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.
References
[1]. estrada aa, chan bk, baker-glenn c, et al. discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (lrrk2) small molecule inhibitors. j med chem, 2014, 57(3): 921-936.
Properties of GNE-9605
| Boiling point: | 587.9±60.0 °C(Predicted) |
| Density | 1.67±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | ≥22.5 mg/mL in DMSO |
| form | solid |
| pka | 5.04±0.60(Predicted) |
| color | White to off-white |
Safety information for GNE-9605
Computed Descriptors for GNE-9605
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