BI-97C1
- CAS NO.:1228108-65-3
- Empirical Formula: C42H40N2O8
- Molecular Weight: 700.78
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is BI-97C1?
The Uses of BI-97C1
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
The Uses of BI-97C1
Sabutoclax is a novel putative MCL-1 inhibitor that induces mitochondrial fragmentation either upstream of or independent of apoptosis.
Biological Activity
sabutoclax is an inhibitor of pan-bcl-2 family with ic50 values of 0.32, 0.31, 0.20 and 0.62 μm for bcl-2, bcl-xl, mcl-1 and bfl-1, respectively [1].sabutoclax is a derivative of apogossypolone. it showed a high binding affinity to bcl-xl both in nmr binding assay and in itc assay, with a kd value of 0.11μm. sabutoclax also showed better cell membrane permeability than other apogossypolone derivatives. in pc3 cells, sabutoclax inhibited cell growth with ec50 value of 0.13 μm. in human bp3 cell line, sabutoclax induced cell apoptosis with ic50 value of 0.049 μm. in mice bearing m2182 cancer xenografts, administration of sabutoclax significantly reduced the tumor size. at dose of 5 mg/kg, sabutoclax induced near complete tumor growth suppression [1].
References
[1] wei j, stebbins j l, kitada s, et al. bi-97c1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic b-cell lymphoma/leukemia-2 (bcl-2) family proteins. journal of medicinal chemistry, 2010, 53(10): 4166-4176.
Properties of BI-97C1
Melting point: | >130°C (dec.) |
Boiling point: | 905.9±65.0 °C(Predicted) |
Density | 1.358±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
form | Solid |
pka | 7.35±0.50(Predicted) |
color | Light Brown to Brown |
Safety information for BI-97C1
Computed Descriptors for BI-97C1
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2,2-diethoxyethanethioamide Tubulysin G Tubulysin B 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE 4-(Benzyloxy)-3-bromophenylacetic Acid 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-(2-Formylphenoxy) acetic acid 1-Aminoindan Hydrochloride Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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