Sodium periodate

Description

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.

Chemical properties

white powder

Chemical properties

Sodium periodate Na2H3IO6, is formed by reaction of sodium iodate plus sodium hydroxide plus chlorine (sodium chloride also formed), and the periodate separates as crystals from the medium. In solution, it is stated, periodate gradually forms ozone and iodate at the ordinary temperatures.

The Uses of Sodium periodate

Sodium Periodate is the sodium salt of periodic acid used to oxidize cellulose. Sodium Periodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.

The Uses of Sodium periodate

The SM (1.03 g, 3.58 mmol), NaIO4 (2.34 g, 10.9 mmol), OsO4 (2.5 wt% in t-BuOH, 1.0 mL), THF (12.4 mL), and H2O (2.4 mL) were combined at RT. The reaction mixture was stirred overnight in the dark, after which time it was diluted with H2O and DCM. The layers were separated using a hydrophobic frit. The org layer was dried (Na2SO4) and concentrated. The residue was purified by silica gel flash chromatography to provide the product as an amber oil. [786 mg, 76%]

The Uses of Sodium periodate

Oxidimetric standard; determination of manganese.

The Uses of Sodium periodate

Sodium metaperiodate is used as an oxidizing reagent involved in the oxidation of cellulose. It is involved in the cleavage of vicinal diols to prepare two aldehydes. This oxidation is commonly used in selectively label RNA, saccharides and other compounds with vicinal diols.

What are the applications of Application

Sodium periodate is a strong oxidizing hypervalent iodine compound

Definition

ChEBI: An inorganic sodium salt having periodate as the counterion.

General Description

Sodium periodate (sodium (meta)periodate) supported on silica gel is a solid supported reagent. It may be synthesized by adding silica gel to hot aqueous solution of sodium metaperiodate and evaporating to dryness followed by vigorous swirling and shaking.

Hazard

Fire risk in contact with organic materials. Toxic by ingestion.

Flammability and Explosibility

Non flammable

Purification Methods

Recrystallise it from hot water. [Willard Inorg Synth I 170 1939, Bernays Inorg Synth II 212 1946.]