Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listSilver sulfadiazine

Silver sulfadiazine

Synonym(s):Silver sulfadiazine;Silver(I) sulfadiazine;Sulfadiazine silver

  • CAS NO.:22199-08-2
  • Empirical Formula: C10H9AgN4O2S
  • Molecular Weight: 357.14
  • MDL number: MFCD00072101
  • EINECS: 244-834-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
Silver sulfadiazine Structural

What is Silver sulfadiazine?

Absorption

Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.

Toxicity

Acute oral toxicity (LD50) in rat is 10001 mg/kg.

Chemical properties

solid

The Uses of Silver sulfadiazine

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

The Uses of Silver sulfadiazine

Coordination compound. Antibacterial

The Uses of Silver sulfadiazine

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.

Background

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.

Indications

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.

What are the applications of Application

Sulfadiazine Silver Salt is An antibacterial

Indications

Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell wall. It is used primarily as an adjunct in the prevention and treatment of wound sepsis in patients with second- and third-degree burns and for wound care of chronic ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those sensitive to silver nitrate but resistant to sulfadiazine, have shown good response to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance, and does not cause systemic acidosis. Some patients note a stinging sensation on application, and because this compound can be absorbed, systemic sulfonamide reactions similar to those caused by sulfonamides may occur.

Definition

ChEBI: Silver(1+) sulfadiazinate is a silver salt, a sulfonamidate and a member of pyrimidines. It has a role as an antimicrobial agent and an antibacterial drug. It contains a sulfadiazinate.

Pharmaceutical Applications

Silver sulfadiazine is extremely insoluble. In addition to the usual activity of sulfonamides it exhibits activity – almost certainly attributable to the silver component – against Ps. aeruginosa and some fungi.
It is variably absorbed after topical application depending on the integrity of the skin. Toxic concentrations may be achieved in patients with extensive burns. It is used topically, mainly for burns, pressure sores and leg ulcers. Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have been developed to reduce bacterial colonization. Other suggested uses include the prevention of infection in skin graft donor sites and cord care in newborn infants.

Pharmaceutical Applications

Silver sulfadiazine is indicated for the prophylaxis and treatment of infections in burn wounds. Silver sulfadiazine is highly insoluble in water, and as a result, it does not cause hypochloraemia in burns in contrast to silver nitrate.
The active ingredient silver sulfadiazine is a sulfur-derived topical antibacterial used primarily on secondand third-degree burns. It is known to be active against many Gram-negative and Gram-positive bacteria as well as against yeast. The cream is kept applied to the burned skin at all times for the duration of the healing period or until a graft is applied. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin. Caution has to be given to large-area application as sulfadiazine levels in the plasma may well reach therapeutic levels that can cause side effects.

Pharmacokinetics

Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.

Clinical Use

The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.

Veterinary Drugs and Treatments

Silver sulfadiazine cream is a broad spectrum agent which covers bacteria (gram positive and negative) and fungal agents. It has been used extensively in people suffering from skin burns. It is nontoxic to the skin, conjunctiva and cornea and has been used in the last several years for cases of fungal keratitis. Particularly good results have been noted in cases of superficial keratitis prior to development of advanced disease. Clinical response is better when used early in the course of the disease. Treatment with silver sulfadiazine is considered non-conventional in people. It is gaining in popularity in the treatment of equine fungal keratitis by veterinary ophthalmologists. For medico-legal reasons, in very expensive horses in which litigation may be an issue, treatment with more conventional therapy (natamycin) may be indicated first, or consideration can be given to signed consent regarding treatment with silver sulfadiazine. The initial response to this drug has been promising, however.

Veterinary Drugs and Treatments

Topical silver sulfadiazine (SSD) is used topically for prophylaxis and treatment of 2nd and 3rd degree burns. It is also useful in treating localized pyodermas caused by Pseudomonas spp.
SSD has extensive antimicrobial activity and is bactericidal for yeasts and many gram-negative and gram-positive bacteria. SSD acts via disrupting microbial cell membranes and cell walls; this differs from the antibacterial actions of silver nitrate or sodium sulfadiazine.

Metabolism

Not Available

Properties of Silver sulfadiazine

Melting point: 285 °C (dec.)(lit.)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  powder
color  White to Off-White
Merck  14,8903
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 22199-08-2(CAS DataBase Reference)

Safety information for Silver sulfadiazine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Silver sulfadiazine

InChIKey UEJSSZHHYBHCEL-UHFFFAOYSA-N

Abamectin manufacturer

Evans Fine Chem

1Y
Phone:+919821340302
Whatsapp: +91 9821340302
product: 22199-08-2 SILVER SULPHADIAIZINE 99%
Inquiry

India Phosphate

1Y
Phone:+91-9993319656
Whatsapp: +91 9993319656
product: 22199-08-2 99%
Inquiry

Dhara Industries

1Y
Phone:+91-9322395199
Whatsapp: +91 9322395199
product: Sulfadiazine silver salt 99%
Inquiry

JPN Pharma Pvt Ltd

1Y
Phone:+919833233531
Whatsapp: +91-9833233531
product: Sulfadiazine silver salt 22199-08-2 98%
Inquiry

Macsen Labs

1Y
Phone:+91-9309241616
Whatsapp: +91 9309241616
product: 22199-08-2 Sulfadiazine silver salt 99%
Inquiry

Chempifine Chemicals

1Y
Phone:+91-2225667766
product: 22199-08-2 98%
Inquiry

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: Sulfadiazine silver salt 98%
Inquiry

Anuja Healthcare Ltd

1Y
Phone:+91-9815004047
Whatsapp: +91 9815004047
product: Sulfadiazine silver salt 22199-08-2 98%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 22199-08-2 Sulfadiazine silver salt 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.