(S)-(+)-alpha-Methoxyphenylacetic acid
Synonym(s):O-Methyl-L -mandelic acid
- CAS NO.：26164-26-1
- Empirical Formula: C9H10O3
- Molecular Weight: 166.17
- MDL number: MFCD00064216
- EINECS: 247-492-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (S)-(+)-alpha-Methoxyphenylacetic acid?
Chemical properties
White Solid
The Uses of (S)-(+)-alpha-Methoxyphenylacetic acid
(S)-(+)-α-Methoxyphenylacetic Acid (cas# 26164-26-1) is a compound useful in organic synthesis.
The Uses of (S)-(+)-alpha-Methoxyphenylacetic acid
Reactant involved in the synthesis of biologically active molecules including:
- Acyclonucleoside phosphonates structural analogs of adefovir
- Labeled discodermolide for studying binding to tubulin
- 10-Isocyano-4-cadinene used for antifouling activity
Reactant involved in studies of immunostimulating chromanones gonytolides A-C
Reactant involved in:
- Hydroxylations and epoxidations
- Hydrogenations
Purification Methods
Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]
Properties of (S)-(+)-alpha-Methoxyphenylacetic acid
| Melting point: | 64-66 °C(lit.) |
| Boiling point: | 164-166°C 18mm |
| alpha | 160 º (C=1, MEOH) |
| Density | 1.1708 (rough estimate) |
| refractive index | 147 ° (C=0.5, EtOH) |
| Flash point: | 164-166°C/18mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethanol (Slightly) |
| form | Fine Crystalline Powder or Crystals |
| pka | 3.10±0.10(Predicted) |
| color | White |
| optical activity | [α]17/D +150°, c = 1 in ethanol |
| Water Solubility | Soluble |
| BRN | 2361718 |
| CAS DataBase Reference | 26164-26-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzeneacetic acid, «alpha»-methoxy-, (s)-(26164-26-1) |
Safety information for (S)-(+)-alpha-Methoxyphenylacetic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-(+)-alpha-Methoxyphenylacetic acid
New Products
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