Phenylacetic acid
Synonym(s):α-Toluic acid;α-Tolylic acid;Benzeneacetic acid;PAA;Phenylacetic acid
- CAS NO.:103-82-2
- Empirical Formula: C8H8O2
- Molecular Weight: 136.15
- MDL number: MFCD00004313
- EINECS: 203-148-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-28 16:31:44
What is Phenylacetic acid?
Toxicity
Acute oral toxicity (LD50): 2250 mg/kg [Mouse].
The Uses of Phenylacetic acid
Phenylacetic Acid is used in the synthesis of Diclofenac (D436450) and its metabolite 4'-Hydroxydiclofenac (H825225), which is the principal human metabolite of Diclofenac.
Background
Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a disagreeable odor. Because it is used in the illicit production of phenylacetone (used in the manufacture of substituted amphetamines), it is subject to controls in countries including the United States and China.
Indications
For use as adjunctive therapy for the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle.
Metabolism
Phenylacetate esterases found in the human liver cytosol. Human plasma esterase also hydrolyze phenylacetate. Phenylacetate hydrolysis involved arylesterase in plasma, both arylesterase and carboxylesterase in liver microsomes and carboxylesterase in liver cytosol. Plasma hydrolysis is less important and overall esterase activity is lower in humans than in the rat.
Properties of Phenylacetic acid
Melting point: | 76-78 °C(lit.) |
Boiling point: | 265 °C(lit.) |
Density | 1.081 g/mL at 25 °C(lit.) |
Flash point: | 132°C |
storage temp. | Store at RT. |
form | neat |
color | Leaflets on distillation in vac; plates, tablets from pet ether |
Odor | disagreeable odor of geranium |
Water Solubility | 15 g/L (20 ºC) |
Safety information for Phenylacetic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Phenylacetic acid
New Products
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