Ro 41-5253

Synonym(s):4-(2-(7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)-1-propenyl)-Benzoic acid, S,S-dioxide;4-[(1E)-2-[7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-benzoic acid;4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoic acid;

CAS NO.：144092-31-9
Empirical Formula: C28H36O5S
Molecular Weight: 484.65
MDL number: MFCD00926134
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:19

What is Ro 41-5253?

Description

Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1?Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2?Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.

The Uses of Ro 41-5253

Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.

What are the applications of Application

Ro 41-5253 is Ro 41-5253 is an inhibitor of RAR α.

Definition

ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.

References

1) Apfel?et al. (1992),?A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA,?89?7129 2) Toma?et al. (1998),?RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer,?78?86

Properties of Ro 41-5253

storage temp.	-20°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.