TTNPB (Arotinoid Acid)

Synonym(s):4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid;Arotinoid acid;TTNPB - CAS 71441-28-6 - Calbiochem

CAS NO.：71441-28-6
Empirical Formula: C24H28O2
Molecular Weight: 348.48
MDL number: MFCD00673917
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

What is TTNPB (Arotinoid Acid)?

The Uses of TTNPB (Arotinoid Acid)

TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors.

What are the applications of Application

TTNPB is a synthetic stilbene analog of retinoic acid (RA) that acts as a potent retinoic acid receptor (RAR) agonist

Definition

ChEBI: A retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).

Biological Activity

Extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype.

Biochem/physiol Actions

Selective and highly potent retinoic acid analog with affinity for retinoic acid receptors (RAR) α, β, and γ, which are nuclear transcription factors. Produces ligand-activated transcription of genes that possess retinoic acid responsive elements.

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.

storage

Desiccate at -20°C

References

[1] pignatello m a, kauffman f c, levin a a. multiple factors contribute to the toxicity of the aromatic retinoid, ttnpb (ro 13-7410): binding affinities and disposition. toxicology and applied pharmacology, 1997, 142(2): 319-327.

Properties of TTNPB (Arotinoid Acid)

Melting point:	242 °C
Boiling point:	422.83°C (rough estimate)
Density	1.0932 (rough estimate)
refractive index	1.4480 (estimate)
storage temp.	-20°C
solubility	chloroform/methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to light yellow
form	White solid
pka	4.28±0.10(Predicted)
color	White to Almost white
CAS DataBase Reference	71441-28-6

Safety information for TTNPB (Arotinoid Acid)

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H360:Reproductive toxicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.