Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list4-HYDROXYPHENYLRETINAMIDE

4-HYDROXYPHENYLRETINAMIDE

Synonym(s):HPR;Fenretinide;Fenretinide, 4HPR, N-(4-Hydroxyphenyl)-all- trans Retinamide;Haptoglobin-related protein;4-HPR

  • CAS NO.:65646-68-6
  • Empirical Formula: C26H33NO2
  • Molecular Weight: 391.55
  • MDL number: MFCD00792674
  • EINECS: 200-256-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
4-HYDROXYPHENYLRETINAMIDE Structural

What is 4-HYDROXYPHENYLRETINAMIDE?

Chemical properties

4-HYDROXYPHENYLRETINAMIDE is Yellow Powder

The Uses of 4-HYDROXYPHENYLRETINAMIDE

4-HYDROXYPHENYLRETINAMIDE is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer

The Uses of 4-HYDROXYPHENYLRETINAMIDE

A synthetic analog of Vitamin A.

The Uses of 4-HYDROXYPHENYLRETINAMIDE

Retinoic acid receptor ligand

What are the applications of Application

4-Hydroxyphenylretinamide is an agonist displaying activity at retinoid receptors

Definition

ChEBI: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in ivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

General Description

Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.

Biological Activity

Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo . Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Biochem/physiol Actions

Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.

storage

Store at -20°C

References

[1] roberto benelli, stefano monteghirfo, roberta venè, francesca tosettiand nicoletta ferrari.the chemopreventive retinoid 4hpr impairs prostate cancer cell migration and invasion by interfering with fak/akt/gsk3β pathway andβ-catenin stability. molecular cancer.2010, 9:142-154.
[2] anita l. sabichi, denver t. hendricks, mary a. bober, michael j. birrer. retinoic acid receptorβexpression and growthinhibition of gynecologic cancer cells by thesynthetic retinoidn-(4-hydroxyphenyl) retinamide. journal of the national cancer institute. 1998, 90(8): 597-605.
[3] shi-yong sun, ping yue, and reuben lotan. induction of apoptosis by n-(4-hydroxyphenyl)retinamide andits association with reactive oxygen species, nuclearretinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.molecular pharmacology. 1999, 55:403–410.

Properties of 4-HYDROXYPHENYLRETINAMIDE

Melting point: 162-163°C
Boiling point: 597.6±42.0 °C(Predicted)
Density  1.081±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Orange solid
pka 9.98±0.26(Predicted)
color  Yellow
λmax 362nm(MeOH)(lit.)
Merck  14,3998
Stability: Light Sensitive - Protect from Light Exposure
CAS DataBase Reference 65646-68-6(CAS DataBase Reference)

Safety information for 4-HYDROXYPHENYLRETINAMIDE

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for 4-HYDROXYPHENYLRETINAMIDE

InChIKey AKJHMTWEGVYYSE-FXILSDISSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.