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HomeProduct name listPropylene carbonate

Propylene carbonate

Synonym(s):1,2-Propanediol cyclic carbonate;4-Methyl-1,3-dioxolan-2-one;4-Methyl-1,3-dioxolan-2-one, Propylene glycol carbonate, Carbonic acid propylene glycol ester;PC;Propylene carbonate

  • CAS NO.:108-32-7
  • Empirical Formula: C4H6O3
  • Molecular Weight: 102.09
  • MDL number: MFCD00005385
  • EINECS: 203-572-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:32
Propylene carbonate  Structural

What is Propylene carbonate ?

Chemical properties

Propylene carbonate is a clear, colorless, mobile liquid, with a faint odor.

The Uses of Propylene carbonate

propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent. It is also used in the synthesis of solar cells as well as lithium ion batteries.

What are the applications of Application

Propylene carbonate is a polar, aprotic solvent used in electrolysis

Production Methods

Propylene carbonate may be prepared by the reaction of sodium bicarbonate with propylene chlorohydrin.

General Description

Propylene carbonate is a cyclic carbonate that is commonly used as a solvent and as a reactive intermediate in organic synthesis. It is being considered as a potential electrochemical solvent due to its low vapor pressure, high dielectric constant and high chemical stability.
Propylene carbonate can be synthesized from propylene oxide and CO2. Optically active form of propylene carbonate can be prepared from the reaction between CO2 and racemic epoxides. Decomposition of propylene carbonate on the graphite electrode in lithium batteries results in the formation of a lithium intercalated compound.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Propylene carbonate is used mainly as a solvent in oral and topical pharmaceutical formulations.
In topical applications, propylene carbonate has been used in combination with propylene glycol as a solvent for corticosteroids. The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene carbonate has been used as a dispensing solvent in topical preparations.
Propylene carbonate has also been used in hard gelatin capsules as a nonvolatile, stabilizing, liquid carrier. For formulations with a low dosage of active drug, a uniform drug content may be obtained by dissolving the drug in propylene carbonate and then spraying this solution on to a solid carrier such as compressible sugar; the sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at room and elevated temperatures, for many cellulose-based polymers and plasticizers. Propylene carbonate is also used in cosmetics.

Safety

Propylene Carbonate is listed in The Design for the Environment (DfE) Safer Chemistry Program by the EPA as a Solvent category and indicated by the Green circle, meaning the chemical has been verified to be of low concern for human and environmental health based on experimental and modeled data.
In animal studies, propylene carbonate was found to cause tissue necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg

storage

Propylene carbonate and its aqueous solutions are stable but may degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place.

Purification Methods

It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.]

Incompatibilities

Propylene carbonate hydrolyzes rapidly in the presence of strong acids and bases, forming mainly propylene oxide and carbon dioxide. Propylene carbonate can also react with primary and secondary amines to yield carbamates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical ointments). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Properties of Propylene carbonate

Melting point: -55 °C (lit.)
Boiling point: 240 °C (lit.)
Density  1.204 g/mL at 25 °C (lit.)
vapor pressure  0.13 mm Hg ( 20 °C)
refractive index  n20/D 1.421(lit.)
Flash point: 270 °F
storage temp.  Store below +30°C.
solubility  240g/l
form  Liquid
pka 3.92[at 20 ℃]
Specific Gravity 1.209 (20/4℃)
color  Clear
PH 7.0 (200g/l, H2O, 20℃)
Odor odorless
Relative polarity 6
explosive limit 1.8-14.3%(V)
Water Solubility  240 g/L (20 ºC)
λmax λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01
BRN  107913
Dielectric constant 64.4(Ambient)
Stability: Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water.
CAS DataBase Reference 108-32-7(CAS DataBase Reference)
NIST Chemistry Reference Propylene carbonate(108-32-7)
EPA Substance Registry System Propylene carbonate (108-32-7)

Safety information for Propylene carbonate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Propylene carbonate

InChIKey RUOJZAUFBMNUDX-UHFFFAOYSA-N

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