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HomeProduct name listPrednisolone succinate

Prednisolone succinate

Synonym(s):Δ1-Hydrocortisone 21-hemisuccinate;(11β)-11,17-Dihydroxy-21-[(3,3-dimethyl-1-oxobutyl)oxy]pregna-1,4-diene-3,20-dione;1,4-Pregnadiene-11β,17,21-triol-3,20-dione 21-hemisuccinate;11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate;Prednisolone 21-hemisuccinate

  • CAS NO.:2920-86-7
  • Empirical Formula: C25H32O8
  • Molecular Weight: 460.52
  • MDL number: MFCD00056465
  • EINECS: 220-861-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
Prednisolone succinate Structural

What is Prednisolone succinate?

The Uses of Prednisolone succinate

neuroleptic

The Uses of Prednisolone succinate

Prednisolone hemisuccinate, is a metabolite of Prednisolone (P703740), which is a synthetic glucocorticoid, a derivative of cortisol, and can be used to treat a variety of inflammatory and auto-immune conditions. It is also the active metabolite of the drug prednisone.

Definition

ChEBI: Prednisolone succinate is a hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns. It has a role as an anti-inflammatory drug. It is a hemisuccinate, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a prednisolone and a succinic acid. It is a conjugate acid of a prednisolone succinate(1-).

Properties of Prednisolone succinate

Melting point: 206°C
Boiling point: 485.35°C (rough estimate)
alpha  [α]D20 +99~+104゜ (c=0.5, 1,4-dioxane)
Density  1.1796 (rough estimate)
refractive index  1.4480 (estimate)
storage temp.  Refrigerator
solubility  DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka 4.29±0.17(Predicted)
form  Solid
color  White to Off-White
CAS DataBase Reference 2920-86-7(CAS DataBase Reference)

Safety information for Prednisolone succinate

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Prednisolone succinate

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