Prednisolone succinate
Synonym(s):Δ1-Hydrocortisone 21-hemisuccinate;(11β)-11,17-Dihydroxy-21-[(3,3-dimethyl-1-oxobutyl)oxy]pregna-1,4-diene-3,20-dione;1,4-Pregnadiene-11β,17,21-triol-3,20-dione 21-hemisuccinate;11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate;Prednisolone 21-hemisuccinate
- CAS NO.：2920-86-7
- Empirical Formula: C25H32O8
- Molecular Weight: 460.52
- MDL number: MFCD00056465
- EINECS: 220-861-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:11
What is Prednisolone succinate?
The Uses of Prednisolone succinate
neuroleptic
The Uses of Prednisolone succinate
Prednisolone hemisuccinate, is a metabolite of Prednisolone (P703740), which is a synthetic glucocorticoid, a derivative of cortisol, and can be used to treat a variety of inflammatory and auto-immune conditions. It is also the active metabolite of the drug prednisone.
Definition
ChEBI: Prednisolone succinate is a hemisuccinate resulting from the formal condensation of the 21-hydroxy group prednisolone with one of the carboxy groups of succinic acid. It is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns. It has a role as an anti-inflammatory drug. It is a hemisuccinate, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a prednisolone and a succinic acid. It is a conjugate acid of a prednisolone succinate(1-).
Properties of Prednisolone succinate
| Melting point: | 206°C |
| Boiling point: | 485.35°C (rough estimate) |
| alpha | [α]D20 +99～+104゜ (c=0.5, 1,4-dioxane) |
| Density | 1.1796 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pka | 4.29±0.17(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 2920-86-7(CAS DataBase Reference) |
Safety information for Prednisolone succinate
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Prednisolone succinate
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