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HomeProduct name listMethylprednisolone sodium succinate

Methylprednisolone sodium succinate

Synonym(s):6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate;6α-Methylprednisolone sodium succinate;MPSL

  • CAS NO.:2375-03-3
  • Empirical Formula: C26H33O8.Na
  • Molecular Weight: 496.53
  • MDL number: MFCD00152612
  • EINECS: 219-156-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Methylprednisolone sodium succinate Structural

What is Methylprednisolone sodium succinate?

Description

Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.

The Uses of Methylprednisolone sodium succinate

6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.

The Uses of Methylprednisolone sodium succinate

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

What are the applications of Application

6α-Methylprednisolone 21-hemisuccinate sodium salt is a glucocorticoid

Definition

ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone.

brand name

A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Side Effects

Methylprednisolone Sodium Succinate is commonly given by injection and common side effects include: injection site pain/redness/swelling, nausea, vomiting, heartburn, headache, dizziness, difficulty sleeping, appetite changes, increased sweating, acne, increased blood sugar, sore throat, fever, chills, cough, white spots in the mouth. Serious side effects manifest as abnormal weight gain, menstrual disorders, bone/joint pain, easy bruising/bleeding, mental/mood changes, fast/slow/irregular heartbeat, stomach/intestinal bleeding symptoms, seizures, liver problems, and symptoms of severe allergic reactions. Contact your doctor if any of these serious adverse symptoms occur.

Properties of Methylprednisolone sodium succinate

Melting point: >186°C (dec.)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  lyophilized powder
color  White to Off-White
CAS DataBase Reference 2375-03-3(CAS DataBase Reference)

Safety information for Methylprednisolone sodium succinate

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Methylprednisolone sodium succinate

InChIKey FQISKWAFAHGMGT-JXAFMBTDNA-M
SMILES [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r|

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