Phlorizin dihydrate
- CAS NO.：7061-54-3
- Empirical Formula: C21H26O11
- Molecular Weight: 454.43
- MDL number: MFCD00006591
- EINECS: 628-113-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 18:13:23
What is Phlorizin dihydrate?
The Uses of Phlorizin dihydrate
Phloridzin dihydrate has been used as:
- a Na+-glucose cotransport inhibitor to test its effect in lowering blood glucose
- a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells
- a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity
What are the applications of Application
Phloridzin dihydrate is a blocker of kidney glucose reabsorption
Biochem/physiol Actions
Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin.
Properties of Phlorizin dihydrate
| Melting point: | 113-114 °C(lit.) |
| alpha | -52 º (c=3, EtOH) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | neat |
| form | Solid |
| color | White to off-white |
| optical activity | [α]20/D 52°, c = 3 in ethanol |
| BRN | 66621 |
| CAS DataBase Reference | 7061-54-3(CAS DataBase Reference) |
Safety information for Phlorizin dihydrate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Phlorizin dihydrate
New Products
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