Wogonin
Synonym(s):5,7-Dihydroxy-8-methoxyflavone;5,7-Dihydroxy-8-methoxyflavone, WOG;Wogonin, S. baicalensis - CAS 632-85-9 - Calbiochem
- CAS NO.：632-85-9
- Empirical Formula: C16H12O5
- Molecular Weight: 284.26
- MDL number: MFCD00017736
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Wogonin?
The Uses of Wogonin
Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia.
What are the applications of Application
Wogonin, S. baicalensis is a flavonoid that displays anti-inflammatory properties
What are the applications of Application
Wogonin is an anti-inflammatory agent and inhibitor of COX-2
Definition
ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
General Description
Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots.
Biochem/physiol Actions
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.
storage
Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Properties of Wogonin
| Melting point: | 203-206°C |
| Boiling point: | 518.8±50.0 °C(Predicted) |
| Density | 1.420±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | Yellow solid |
| pka | 6.83±0.40(Predicted) |
| color | Light Yellow to Yellow |
| λmax | 319nm(EtOH)(lit.) |
| CAS DataBase Reference | 632-85-9(CAS DataBase Reference) |
Safety information for Wogonin
Computed Descriptors for Wogonin
| InChIKey | XLTFNNCXVBYBSX-UHFFFAOYSA-N |
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