Wogonin

Synonym(s):5,7-Dihydroxy-8-methoxyflavone;5,7-Dihydroxy-8-methoxyflavone, WOG;Wogonin, S. baicalensis - CAS 632-85-9 - Calbiochem

CAS NO.：632-85-9
Empirical Formula: C16H12O5
Molecular Weight: 284.26
MDL number: MFCD00017736
EINECS: 1592732-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is Wogonin?

The Uses of Wogonin

Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia.

What are the applications of Application

Wogonin, S. baicalensis is a flavonoid that displays anti-inflammatory properties

What are the applications of Application

Wogonin is an anti-inflammatory agent and inhibitor of COX-2

Definition

ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.

General Description

Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots.

Biochem/physiol Actions

Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.

storage

Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Properties of Wogonin

Melting point:	203-206°C
Boiling point:	518.8±50.0 °C(Predicted)
Density	1.420±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO: ≥20mg/mL
form	Yellow solid
pka	6.83±0.40(Predicted)
color	Light Yellow to Yellow
λmax	319nm(EtOH)(lit.)
CAS DataBase Reference	632-85-9(CAS DataBase Reference)