Permethrin

Synonym(s):Permethrin;RGM domain family member B;RGMB

CAS NO.：52645-53-1
Empirical Formula: C21H20Cl2O3
Molecular Weight: 391.29
MDL number: MFCD00041809
EINECS: 258-067-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-25 14:54:50

What is Permethrin?

Absorption

Poorly absorbed through the skin.

Toxicity

Oral, rat LD50: 430 - 4000 mg/kg; skin, rabbit LD50: 2000 mg/kg.

Indications

For the treatment of infestation with Sarcoptes scabiei (scabies).

Background

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Pharmacokinetics

Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.

Side Effects

Skin irritation, including itching, swelling, and redness, may occur with scabies and temporarily worsen after treatment with permethrin. Mild burning or stinging may also occur.

Metabolism

Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.

The Uses of Permethrin

Permethrin is used to treat scabies, a condition caused by tiny insects called mites that infest and irritate your skin.

Properties of Permethrin

Melting point:	34-35°C
Boiling point:	bp0.05 220°
Density	1.19
vapor pressure	7×10^-5 Pa (20 °C)
refractive index	1.6500 (estimate)
Flash point:	10 °C
storage temp.	0-6°C
solubility	DMF: 33 mg/ml; DMSO: 16 mg/ml; Ethanol: 14 mg/ml
form	Liquid
form	neat
color	Light yellow to yellow
Water Solubility	insoluble
Merck	13,7257
BRN	5765325
Stability:	Stable. Incompatible with strong oxidising agents.
CAS DataBase Reference	52645-53-1(CAS DataBase Reference)
NIST Chemistry Reference	Permethrin(52645-53-1)
IARC	3 (Vol. 53) 1991
EPA Substance Registry System	Permethrin (52645-53-1)

Safety information for Permethrin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water.