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HomeProduct name listPD 123319 ditrifluoroacetate

PD 123319 ditrifluoroacetate

PD 123319 ditrifluoroacetate Structural

What is PD 123319 ditrifluoroacetate?

The Uses of PD 123319 ditrifluoroacetate

PD 123319 is a selective non-peptide angiotensin AT2 receptor antagonist.

What are the applications of Application

PD 123319 ditrifluoroacetate is a selective non-peptide angiotensin AT2 receptor antagonist

Definition

ChEBI: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively

Biological Activity

Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

References

[1] blankley c j, hodges j c, klutchko s r, et al. synthesis and structure-activity relationships of a novel series of non-peptide angiotensin ii receptor binding inhibitors specific for the at2 subtype. journal of medicinal chemistry, 1991, 34(11): 3248-3260.
[2] boulay g, servant g, luong t t, et al. modulation of angiotensin ii binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the dup-753-sensitive angiotensin ii receptor of bovine adrenal glomerulosa. molecular pharmacology, 1992, 41(4): 809-815.
[3] siragy h. angiotensin ii receptor blockers: review of the binding characteristics. the american journal of cardiology, 1999, 84(10): 3-8.

Properties of PD 123319 ditrifluoroacetate

Boiling point: 775.8±60.0 °C(Predicted)
Density  1.22±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: 12 mg/mL
pka 2.80±0.20(Predicted)
form  powder
Water Solubility  Soluble to 100 mM in water

Safety information for PD 123319 ditrifluoroacetate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PD 123319 ditrifluoroacetate

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