2-METHOXYESTRADIOL

Chemical properties

Off-White Solid

The Uses of 2-METHOXYESTRADIOL

A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a

The Uses of 2-METHOXYESTRADIOL

2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

The Uses of 2-METHOXYESTRADIOL

A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly

The Uses of 2-METHOXYESTRADIOL

2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.

The Uses of 2-METHOXYESTRADIOL

2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Definition

ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.

What are the applications of Application

2-Methoxyestradiol is a disruptor of microtubule function and HIF-1 inhibitor

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.