OSI-420
- CAS NO.：183320-51-6
- Empirical Formula: C21H22ClN3O4
- Molecular Weight: 415.87
- MDL number: MFCD22420811
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-27 15:38:00
What is OSI-420?
The Uses of OSI-420
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
The Uses of OSI-420
OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.
Properties of OSI-420
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (120.23 mM; Need ultrasonic) |
| form | Powder |
| color | White to off-white |
Safety information for OSI-420
Computed Descriptors for OSI-420
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
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