OSI-420
- CAS NO.：183320-51-6
- Empirical Formula: C21H22ClN3O4
- Molecular Weight: 415.87
- MDL number: MFCD22420811
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is OSI-420?
The Uses of OSI-420
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
The Uses of OSI-420
OSI 420 can be used in biological study of effects of cytochrome P 450 3A on pharmacokinetic interaction between erlotinib and docetaxel in rats.
Properties of OSI-420
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (120.23 mM; Need ultrasonic) |
| form | Powder |
| color | White to off-white |
Safety information for OSI-420
Computed Descriptors for OSI-420
New Products
Tubulysin M Tubulysin F Tubulysin C 2,2-diethoxyethanethioamide Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 4,4-DIFLUOROCYCLOHEXANAMINE 4-(Benzyloxy)-3-bromophenylacetic Acid 3-N-BOC-(S)-AMINO BUTYRONITRILE 2,2-Difluoropropylamine hydrochloride 2H-Pyran, 4-ethynyltetrahydro- (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell 3-(4-Chloro-butyryl) -1H-indole-5- carbonitrile 3-(S)-(+)- (-1-carbamoyl-1, 1-diphenylmethyl)- pyrrolidine-L- tartarate Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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