NU1025

Synonym(s):8-Hydroxy-2-methylquinazolin-4[3H]-one;8-Hydroxy-2-methylquinazoline-4-one;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem

CAS NO.：90417-38-2
Empirical Formula: C9H8N2O2
Molecular Weight: 176.17
MDL number: MFCD00942555
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is NU1025?

Description

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC₅₀ = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.

Chemical properties

Off-White to Pale Yellow Solid

The Uses of NU1025

A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively

The Uses of NU1025

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]

The Uses of NU1025

A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

What are the applications of Application

NU 1025 is a potent PARP-1 and Topo I inhibitor

Definition

ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.

Biological Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

Properties of NU1025

Melting point:	253-258°C
Boiling point:	345.4±44.0 °C(Predicted)
Density	1.42
storage temp.	−20°C
solubility	DMSO: 35 mg/mL, soluble
form	solid
pka	8.68±0.20(Predicted)
color	off-white
CAS DataBase Reference	90417-38-2

Safety information for NU1025

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.