NU1025
Synonym(s):8-Hydroxy-2-methylquinazolin-4[3H]-one;8-Hydroxy-2-methylquinazoline-4-one;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem
- CAS NO.：90417-38-2
- Empirical Formula: C9H8N2O2
- Molecular Weight: 176.17
- MDL number: MFCD00942555
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is NU1025?
Description
NU 1025 is an inhibitor of poly(ADP-
Chemical properties
Off-White to Pale Yellow Solid
The Uses of NU1025
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively
The Uses of NU1025
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]
The Uses of NU1025
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
What are the applications of Application
NU 1025 is a potent PARP-1 and Topo I inhibitor
Definition
ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Biological Activity
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.
Properties of NU1025
| Melting point: | 253-258°C |
| Boiling point: | 345.4±44.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | −20°C |
| solubility | DMSO: 35 mg/mL, soluble |
| form | solid |
| pka | 8.68±0.20(Predicted) |
| color | off-white |
| CAS DataBase Reference | 90417-38-2 |
Safety information for NU1025
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NU1025
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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