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HomeProduct name listABT-888

ABT-888

  • CAS NO.:912445-05-7
  • Empirical Formula: C13H16N4O
  • Molecular Weight: 244.296
  • MDL number: MFCD12407402
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:44:47
ABT-888 Structural

What is ABT-888?

The Uses of ABT-888

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.

What are the applications of Application

ABT-888 is a potent PARP-1 and PARP-2 inhibitor, with excellent bioavailability and blood-brain permeation for in vivo studies.

storage

Store at -20°C

Properties of ABT-888

Melting point: >173°C (dec.)
storage temp.  Refrigerator
solubility  Methanol (Slightly, Heated), THF (Slightly, Heated)
form  Colorless to white crystalline solid.
color  Off-White to Dark Yellow

Safety information for ABT-888

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for ABT-888

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