DPQ
Synonym(s):3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone;3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem
- CAS NO.:129075-73-6
- Empirical Formula: C18H26N2O2
- Molecular Weight: 302.41
- MDL number: MFCD02258932
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is DPQ?
Description
The poly(ADP-
The Uses of DPQ
DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.
The Uses of DPQ
3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.
The Uses of DPQ
Reagent for inhibition of PARP.
What are the applications of Application
DPQ is a highly potent, selective PARP inhibitor
Biochem/physiol Actions
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
storage
+4°C
Properties of DPQ
Melting point: | 107-109° |
Boiling point: | 528.8±50.0 °C(Predicted) |
Density | 1.096±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: Soluble |
form | solid |
pka | 14.54±0.20(Predicted) |
color | White to off-white |
Safety information for DPQ
Computed Descriptors for DPQ
New Products
Tubulysin G (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin B Diethyl Aluminium Cyanide (1.0 M in Toluene) CYCLOBUTYLAMINE HYDROCHLORIDE 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 4,4-DIFLUOROPIPERIDINE 3-Aminocyclobutanone hydrochloride 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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