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HomeProduct name listDPQ

DPQ

Synonym(s):3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone;3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem

DPQ Structural

What is DPQ?

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals.

The Uses of DPQ

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

The Uses of DPQ

3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.

The Uses of DPQ

Reagent for inhibition of PARP.

What are the applications of Application

DPQ is a highly potent, selective PARP inhibitor

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

storage

+4°C

Properties of DPQ

Melting point: 107-109°
Boiling point: 528.8±50.0 °C(Predicted)
Density  1.096±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: Soluble
form  solid
pka 14.54±0.20(Predicted)
color  White to off-white

Safety information for DPQ

Computed Descriptors for DPQ

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