N-Acetyl-L-phenylalanine
- CAS NO.:2018-61-3
- Empirical Formula: C11H13NO3
- Molecular Weight: 207.23
- MDL number: MFCD00063158
- EINECS: 217-959-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-26 08:28:19
What is N-Acetyl-L-phenylalanine?
Chemical properties
white to off-white fine cryst. powder or needles
The Uses of N-Acetyl-L-phenylalanine
N-Acetyl-L-phenylalanine is an protected analogue of L-Phenylalanine (P319415), an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.
The Uses of N-Acetyl-L-phenylalanine
It is an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of aspartame. It is applied as an antidepressant.
Definition
ChEBI: The N-acetyl derivative of L-phenylalanine.
General Description
N-Acetyl-L-phenylalanine is an acetyl analog of L-phenylalanine. It is widely used as a reactant to synthesize methyl or ethyl esters of N-acetyl-L-phenylalanine, which are employed as versatile building blocks in peptide synthesis.
Purification Methods
N-Acetyl-L-phenylalanine is recrystallised from H2O, 20% MeOH/H2O, or CHCl3; dry and store it at 4o. The (DL)-isomer crystallises from H2O, Me2CO, EtOAc, or CHCl3 with m 152-154o and the solubilities in w% at 25o are 0.73 (H2O), 4.3 (Me2CO), 0.79 (EtOAc) and 0.34 (CHCl3) [Kerr & Niemann J Org Chem 23 893 1958, Overby & Ingersoll J Am Chem Soc 73 3363 1951, L: Fu et al. J Am Chem Soc 76 6057 1954, Bender & Glasson J Am Chem Soc 81 1591 1959]. [Beilstein 14 I 238, 4 IV 1575.]
Properties of N-Acetyl-L-phenylalanine
Melting point: | 171-173 °C(lit.) |
Boiling point: | 346.25°C (rough estimate) |
alpha | 40 º (c=1,methanol) |
Density | 1.1878 (rough estimate) |
refractive index | 40 ° (C=5, MeOH) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Solubility in methanol (almost transparency). Soluble in acetone and ethanol (20 mg/ ml). |
form | Fine Crystalline Powder or Needles |
pka | 3.56±0.10(Predicted) |
color | White to off-white |
optical activity | [α]22/D +40.0°, c = 1 in methanol |
CAS DataBase Reference | 2018-61-3(CAS DataBase Reference) |
NIST Chemistry Reference | L-phenylalanine, n-acetyl-(2018-61-3) |
EPA Substance Registry System | L-Phenylalanine, N-acetyl- (2018-61-3) |
Safety information for N-Acetyl-L-phenylalanine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Acetyl-L-phenylalanine
InChIKey | CBQJSKKFNMDLON-JTQLQIEISA-N |
New Products
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