N-(9-Fluorenylmethoxycarbonyloxy)succinimide

Synonym(s):N-(9-Fluorenylmethoxycarbonyloxy)succinimide;9-Fluorenylmethyl N-succinimidyl carbonate;FMOC-ONSu, N-(9H-Fluoren-9-ylmethoxycarbonyloxy)succinimide;Fmoc-OSu;N-(9-Fluorenylmethoxycarbonyloxy)succinimide, 9-Fluorenylmethyl-succinimidyl carbonate

CAS NO.：82911-69-1
Empirical Formula: C19H15NO5
Molecular Weight: 337.33
MDL number: MFCD00010733
EINECS: 433-520-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-15 15:41:51

N-(9-Fluorenylmethoxycarbonyloxy)succinimide Structural

What is N-(9-Fluorenylmethoxycarbonyloxy)succinimide?

Chemical properties

White powder

The Uses of N-(9-Fluorenylmethoxycarbonyloxy)succinimide

N-(9-Fluorenylmethoxycarbonyloxy)succinimide is used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.

The Uses of N-(9-Fluorenylmethoxycarbonyloxy)succinimide

N-protecting reagent for oligonucleotide and peptide syntheses

The Uses of N-(9-Fluorenylmethoxycarbonyloxy)succinimide

Reagent for the preparation of pure Fmoc amino acids free from contamination by Fmoc-dipeptides.

What are the applications of Application

Fmoc N-hydroxysuccinimide ester is an efficient reagent for the selective preparation of N-(9-fluorenylmethoxycarbonyl) derivatives

Purification Methods

Recrystallise the carbonate from CHCl3/Et2O, or from pet ether (b 40-60o). [Pauet Can J Chem 60 976 1982, Lapatsaris et al. Synthesis 671 1983.]

Properties of N-(9-Fluorenylmethoxycarbonyloxy)succinimide

Melting point:	150-153 °C(lit.)
Boiling point:	150-153°C
Density	1.3460 (rough estimate)
refractive index	1.5000 (estimate)
storage temp.	2-8°C
solubility	Soluble in dimethyl sulfoxide and dimethyl formamide.
form	Microfine Powder
color	White or almost white
Sensitive	Moisture Sensitive
BRN	3569540
Stability:	Moisture Sensitive
CAS DataBase Reference	82911-69-1(CAS DataBase Reference)

Safety information for N-(9-Fluorenylmethoxycarbonyloxy)succinimide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water.