N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Synonym(s):JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem;N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
- CAS NO.:312917-14-9
- Empirical Formula: C20H16N2OS
- Molecular Weight: 332.42
- MDL number: MFCD01005305
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide?
Description
JNK inhibitor IX (312917-14-9) inhibits JNK2 and JNK3 via binding to the ATP binding domain. Displays little or no activity against JNK1, p38α and a panel of 30 other kinases.1?Induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells.2
The Uses of N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product.
What are the applications of Application
JNK Inhibitor IX is a selective and potent inhibitor of the ATP binding sites of JNK2 and JNK3
Definition
ChEBI: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide is a naphthalenecarboxamide.
storage
Store at RT
References
1) Angell?et al. (2007),?N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3; Med. Chem. Lett.,?17?1296 2) Jang?et al.?(2014),?Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells?; Biochem. Biophys. Res. Commun.,?452?845
Properties of N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Melting point: | 88-90oC |
Boiling point: | 486.8±45.0 °C(Predicted) |
Density | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming) |
form | Tan solid |
pka | 11.95±0.20(Predicted) |
color | Off-white |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Computed Descriptors for N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
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