AS601245
Synonym(s):JNK Inhibitor V - CAS 345987-15-7 - Calbiochem;SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
- CAS NO.:345987-15-7
- Empirical Formula: C20H16N6S
- Molecular Weight: 372.45
- MDL number: MFCD07772196
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:08
What is AS601245?
The Uses of AS601245
JNK Inhibitor V is an anti-inflammatory JNK inhibitor with neuroprotective properties. JNK Inhibitor V and Clofibrate (C586910) synergistically inhibit proliferation, induce apoptosis and differentiation via differential modulation of gene expression profile in human colon cancer cells.
What are the applications of Application
JNK Inhibitor V is a JNK1, JNK2, and JNK3 inhibitor
Definition
ChEBI: 2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile is a member of benzothiazoles.
Biological Activity
recent evidence suggests activation of the c-jun nh2-terminal protein kinase (jnk) signal transduction pathway may play a role in ischemia-induced cell death. therefore, preventing the activation of jnk, or c-jun phosphorylation could be neuroprotective. as601245 is a c-jun nh2-terminal protein kinase inhibitor.
in vitro
as601245 demonstrated a nonspecific inhibition of the three jnk human isoforms. as601245 inhibits isolated hjnk3 in an atpcompetitive manner. selectivity of as601245 was tested against a large panel of kinases. it exhibited 10- to 20-fold selectivity over c-src, cdk2, and c-raf and more than 50- to 100-fold selectivity over a range of tyr- and ser/thr-protein kinases [1].
in vivo
as601245 administered i.p. provided significant protection against the delayed loss of hippocampal ca1 neurons in a gerbil model of transient global ischemia. this effect is mediated by jnk inhibition and thus by c-jun expression and phosphorylation. a significant neuroprotective effect of as601245 administered either by i.p. injection or as i.v. bolus followed by an i.v. infusion was also observed in rats after focal cerebral ischemia [1].
References
[1] carboni s, hiver a, szyndralewiez c, gaillard p, gotteland jp, vitte pa. as601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-jun nh2-terminal protein kinase inhibitor with neuroprotective properties. j pharmacol exp ther. 2004 jul;310(1):25-32. epub 2004 feb 26.
Properties of AS601245
Boiling point: | 635.6±65.0 °C(Predicted) |
Density | 1.366±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO |
pka | 5.32±0.10(Predicted) |
form | White to yellow solid. |
color | Light yellow to yellow |
Safety information for AS601245
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for AS601245
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