JX401
Synonym(s):N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem
- CAS NO.:349087-34-9
- Empirical Formula: C21H25NO2S
- Molecular Weight: 355.49
- MDL number: MFCD02038777
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is JX401?
Description
JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.
The Uses of JX401
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]
The Uses of JX401
JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.
What are the applications of Application
JX-401 is a potent non-cytotoxic cell membrane permeable p38α inhibitor
Definition
ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.
Biological Activity
Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
storage
Room temperature
References
1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.
Properties of JX401
storage temp. | Store at RT |
solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). |
form | Off-white solid |
color | White |
Stability: | Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for JX401
Computed Descriptors for JX401
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