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HomeProduct name listMinoxidil sulphate

Minoxidil sulphate

  • CAS NO.:83701-22-8
  • Empirical Formula: C9H15N5O4S
  • Molecular Weight: 289.31
  • MDL number: MFCD06248907
  • EINECS: 635-997-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Minoxidil sulphate Structural

What is Minoxidil sulphate?

Chemical properties

White Crystalline Solid

The Uses of Minoxidil sulphate

A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant

The Uses of Minoxidil sulphate

specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite

The Uses of Minoxidil sulphate

Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.

What are the applications of Application

Minoxidil sulfate (U-58838) is a K+ channel agonist and a strong vascular smooth muscle relaxant

Biological Functions

Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.

Biochem/physiol Actions

Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.

in vitro

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

Properties of Minoxidil sulphate

Melting point: 175-180°C
Density  1.75±0.1 g/cm3(Predicted)
RTECS  UV6260494
storage temp.  -20°C
solubility  Acetone (Slightly), DMSO (Slightly)
form  White solid.
pka -4.99±0.18(Predicted)
color  White to Off-White
Stability: Light Sensitive - Protect from Light, Store in Freezer
InChI InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
CAS DataBase Reference 83701-22-8(CAS DataBase Reference)

Safety information for Minoxidil sulphate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Minoxidil sulphate

InChIKey AGMYAAIWWVATKU-UHFFFAOYSA-N
SMILES C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1

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