Minoxidil sulphate
- CAS NO.:83701-22-8
- Empirical Formula: C9H15N5O4S
- Molecular Weight: 289.31
- MDL number: MFCD06248907
- EINECS: 635-997-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Minoxidil sulphate?
Chemical properties
White Crystalline Solid
The Uses of Minoxidil sulphate
A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant
The Uses of Minoxidil sulphate
specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite
The Uses of Minoxidil sulphate
Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.
What are the applications of Application
Minoxidil sulfate (U-58838) is a K+ channel agonist and a strong vascular smooth muscle relaxant
Biological Functions
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.
Biochem/physiol Actions
Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.
in vitro
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Properties of Minoxidil sulphate
Melting point: | 175-180°C |
Density | 1.75±0.1 g/cm3(Predicted) |
RTECS | UV6260494 |
storage temp. | -20°C |
solubility | Acetone (Slightly), DMSO (Slightly) |
form | White solid. |
pka | -4.99±0.18(Predicted) |
color | White to Off-White |
Stability: | Light Sensitive - Protect from Light, Store in Freezer |
InChI | InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17) |
CAS DataBase Reference | 83701-22-8(CAS DataBase Reference) |
Safety information for Minoxidil sulphate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Minoxidil sulphate
InChIKey | AGMYAAIWWVATKU-UHFFFAOYSA-N |
SMILES | C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1 |
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