Methoxycarbonyl-L-tert-leucine

Synonym(s):(2S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid;N-Methoxycarbonyl-3-methyl-L-valine

CAS NO.：162537-11-3
Empirical Formula: C8H15NO4
Molecular Weight: 189.21
MDL number: MFCD07778455
EINECS: 431-620-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:14

Methoxycarbonyl-L-tert-leucine Structural

What is Methoxycarbonyl-L-tert-leucine?

Chemical properties

White Solid

The Uses of Methoxycarbonyl-L-tert-leucine

The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.

Flammability and Explosibility

Not classified

Properties of Methoxycarbonyl-L-tert-leucine

Melting point:	1090C
Boiling point:	320.9±25.0 °C(Predicted)
Density	1.126±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	2-8°C
solubility	Soluble in ethyl acetate and methanol.
form	powder
pka	4.46±0.10(Predicted)
color	White to off-white
Water Solubility	26.4g/L at 20℃
InChI	InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1

Safety information for Methoxycarbonyl-L-tert-leucine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.