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HomeProduct name listMetandienone

Metandienone

Synonym(s):1-Dehydro-17α-methyltestosterone;Dianabol;Methandienone;Methandrostenolone

  • CAS NO.:72-63-9
  • Empirical Formula: C20H28O2
  • Molecular Weight: 300.44
  • MDL number: MFCD00003650
  • EINECS: 200-787-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Metandienone Structural

What is Metandienone?

Chemical properties

White Solid

Originator

Dianabol,Ciba,US,1960

The Uses of Metandienone

Anabolic steroid. Androgen. Controlled substance.

Definition

ChEBI: Methandrostenolone is an organic molecular entity.

Manufacturing Process

As described in US Patent 2,929,763, methandrostenolone may be made by a fermentation route. 2 g of sodium nitrate, 1 g of primary potassium orthophosphate, 0.5 g of magnesium sulfate heptahydrate, 0.5 g of potassium chloride, 50 g of glucose and 1 g of Difco yeast extract are dissolved in one liter of tap water, brought to pH 5 by addition of a sodium hydroxide solution and sterilized. The resulting nutrient solution is inoculated with 50 cc of a 4- day-old shaking culture of Didymella lycopersici and shaken for 48 hours at 27°C, whereby the culture becomes well developed.
To two liters of a culture so prepared there is added under sterile conditions a solution of 500 mg of 17α-methyl-testosterone in 15 cc of acetone. Shaking is carried out for 3 days at 27°C, the mycellium then filtered off with suction, washed with water and ethyl acetate and the combined filtrates extracted with ethyl acetate. The extraction residue obtained after evaporation of the solvent is dissolved in a little acetone. On addition of ether, the 1-dehydro-17αmethyl-testosterone is obtained in compact crystals. MP 163° to 164°C.
An alternative synthetic route is described in US Patent 2,900,398 as follows. A suspension of 30 g of 17α-methyl-testosterone and 10 g of selenium dioxide in 600 cc of tertiary amyl alcohol is treated with 60 g of magnesium powder and 6 cc of glacial acetic acid.
The mixture is refluxed for 24 hours with good stirring in an atmosphere of nitrogen, another 10 g of selenium dioxide being added after 10 hours. After some cooling, the suspension is filtered through some Hyflo and washed thoroughly with ethyl acetate. The resulting brown solution is evaporated in vacuo and the residue dissolved in ethyl acetate.
The ethyl acetate solution is then washed with water, dried and evaporated. To remove any selenium still present, the residue is dissolved in 200 cc of methanol and mixed with 100 g of iron powder and 2 g of active carbon. The mixture is heated for 30 minutes with stirring under reflux, then filtered with suction, washed with methanol and the solution evaporated in vacuo. The residue is then chromatographed on 900 g of aluminum oxide. The residues of the evaporated benzene and ether fractions are treated with active carbon in methanol or acetone, evaporated again, and the residue recrystallized from a mixture of acetone and ether. There are obtained 17.5 g of pure 1-dehydro17α-methyl-testosterone which melts at 163° to 164°C.

Therapeutic Function

Androgen, Anabolic

Properties of Metandienone

Melting point: 165-166 °C
Boiling point: 381.66°C (rough estimate)
Density  1.0597 (rough estimate)
refractive index  1.4800 (estimate)
Flash point: -2℃
storage temp.  2-8°C
solubility  Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
pka 15.12±0.60(Predicted)
form  neat
optical activity [α]1.15/D 0.5±0.5° in chloroform
Merck  5951
BRN  2056255
InChI InChI=1/C20H28O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h6,9,12,15-17,22H,4-5,7-8,10-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/s3
CAS DataBase Reference 72-63-9(CAS DataBase Reference)
NIST Chemistry Reference Methandrostenolone(72-63-9)

Safety information for Metandienone

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H332:Acute toxicity,inhalation
Precautionary Statement Codes P201:Obtain special instructions before use.
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for Metandienone

InChIKey XWALNWXLMVGSFR-HLXURNFRSA-N
SMILES [C@]12(CCC3=CC(=O)C=C[C@]3(C)[C@]1(CC[C@]1(C)[C@](O)(C)CC[C@@]21[H])[H])[H] |&1:0,9,11,14,16,21,r|

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