Madecassic acid

Synonym(s):6β-Hydroxyasiatic acid;Brahmic acid

CAS NO.：18449-41-7
Empirical Formula: C30H48O6
Molecular Weight: 504.71
MDL number: MFCD29048539
EINECS: 240-851-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-26 11:58:42

What is Madecassic acid?

Description

Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E₂ (PGE₂; ), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; ). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.

Chemical properties

White powder

The Uses of Madecassic acid

wound healing

The Uses of Madecassic acid

Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.

The Uses of Madecassic acid

Definition

ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).

What are the applications of Application

Madecassic acid is a natural triterpene immunomodulator and inflammatory agent isolated from C. asiatica..

Properties of Madecassic acid

Melting point:	270°C (dec.)
Boiling point:	641.7±55.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Sparingly), Methanol (Slightly, Heated)
form	Solid
pka	4.63±0.70(Predicted)
color	White to Pale Red

Safety information for Madecassic acid

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P405:Store locked up.