ORIENTIN

Synonym(s):8-β-D-Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavone;Luteolin 8-C-β-D-glucopyranoside;Luteolin-8-glucoside;Lutexin

CAS NO.：28608-75-5
Empirical Formula: C21H20O11
Molecular Weight: 448.38
MDL number: MFCD00017432
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:02:56

What is ORIENTIN?

Description

Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC₅₀ value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC₅₀ value of 11.7 μg/ml and a cytotoxic concentration (CC₅₀) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.

Chemical properties

Yellow powder

The Uses of ORIENTIN

Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.

What are the applications of Application

Orientin is a flavone

Definition

ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.

Properties of ORIENTIN

Melting point:	260-285°C
Boiling point:	816.1±65.0 °C(Predicted)
Density	1.759±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	1 M NaOH: soluble1mg/mL, clear, yellow-orange
form	powder
pka	6.24±0.40(Predicted)
color	yellow
Stability:	Hygroscopic

Safety information for ORIENTIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.