AURANTIO-OBTUSIN
Synonym(s):1,3,7-Trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthracenedione
- CAS NO.：67979-25-3
- Empirical Formula: C17H14O7
- Molecular Weight: 330.29
- MDL number: MFCD13194886
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-15 19:19:13
What is AURANTIO-OBTUSIN?
Description
Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).
The Uses of AURANTIO-OBTUSIN
A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count
Definition
ChEBI: A trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.
Properties of AURANTIO-OBTUSIN
| Melting point: | 265-266 °C |
| Boiling point: | 594.6±50.0 °C(Predicted) |
| Density | 1.510±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in chloroform, DMSO and methan |
| form | powder |
| pka | 6.32±0.20(Predicted) |
| color | Orange |
Safety information for AURANTIO-OBTUSIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for AURANTIO-OBTUSIN
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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