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HomeProduct name listAURANTIO-OBTUSIN

AURANTIO-OBTUSIN

Synonym(s):1,3,7-Trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthracenedione

AURANTIO-OBTUSIN Structural

What is AURANTIO-OBTUSIN?

Description

Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).

The Uses of AURANTIO-OBTUSIN

A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count

Definition

ChEBI: A trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.

Properties of AURANTIO-OBTUSIN

Melting point: 265-266 °C
Boiling point: 594.6±50.0 °C(Predicted)
Density  1.510±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in chloroform, DMSO and methan
form  powder
pka 6.32±0.20(Predicted)
color  Orange

Safety information for AURANTIO-OBTUSIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for AURANTIO-OBTUSIN

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