Licofelone
- CAS NO.:156897-06-2
- Empirical Formula: C23H22ClNO2
- Molecular Weight: 379.88
- MDL number: MFCD00929900
- EINECS: 694-581-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is Licofelone?
Description
Cross-
Chemical properties
Yellowish Solid
The Uses of Licofelone
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory
The Uses of Licofelone
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.
What are the applications of Application
Licofelone is an inhibitor of Cox-1, Cox-2, and 5-lipoxygenase, that causes little or no gastric mucosa damage in rabbit parietal cells.
in vitro
the 5-lox and cox inhibitory effect of licofelone was firstly identified via bovine thromobocyte intact cell assay and intact bovine pmn leukocytes. licofelone was also reported to inhibit pge2 in a dose-dependent manner in human whole blood assay. moreover, licofelone was found to suppress in vitro generation of reactive oxygen species and to reduce release of elastase from pmn leukocytes. all above findings revealed that licofelone had an inhibitory effect on cox-1/-2 and 5-lox. [1]
in vivo
the pharmacodynamic properties of licofelone were evaluated in various animal models and compared with those of commonly used nsaids. based on studies from a rat model of incisional pain, orally administration of licofelone had a longer duration of action and was more effective than indomethacin and zileuton. [1]
References
[1]kulkarni sk and singh vp. licofelone-a novel analgesic and anti-inflammatory agent. curr top med chem. 2007; 7(3): 251-63.
Properties of Licofelone
Melting point: | 162-163°C |
Boiling point: | 539.7±50.0 °C(Predicted) |
Density | 1.23 |
storage temp. | -20°C Freezer |
solubility | Chloroform, Methanol |
pka | 4.47±0.10(Predicted) |
form | Solid |
color | Off-White to Light Yellow |
CAS DataBase Reference | 156897-06-2(CAS DataBase Reference) |
Safety information for Licofelone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Licofelone
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