Levomefolate calcium

Description

Calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca) is a synthetic derivative of folic acid, the predominant, naturally occurring form of folate. L-5-methyltetrahydrofolate, also known as levomefolic acid, is the primary biologically active form of folate. It is involved in many important in vivo process including DNAreproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. It can be used for the treatment of major depressive disorder, cardiovascular disease and cancer. It can be used for the treatment of hyperhomocysteinemia regularly found in hemodialysis patients.

Chemical properties

Off-White to Pale Yellow Solid

The Uses of Levomefolate calcium

The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.

The Uses of Levomefolate calcium

The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid.

What are the applications of Application

L-5-Methyletrahydrofolate calcium is the calcium salt of the most active form of coenzymated Folic Acid.

Definition

ChEBI: Levomefolate calcium is an organic calcium salt of (6S)-5-methyltetrahydrofolic acid. It has a role as an antidepressant. It contains a (6S)-5-methyltetrahydrofolate(2-).

brand name

Products containing levomefolate calcium Brand name: L-Methylfolate Calcium
Multi-ingredient medications containing levomefolate calcium drospirenone/ethinyl estradiol/levomefolate calcium systemic Brand names: Beyaz, Tydemy, Safyral, Rajani

Biological Functions

Levomefolate calcium is the calcium salt of L-5-methyltetrahydrofolic acid, and a member of the folate group of vitamins (Vitamin B9). It is the coenzymated and most active form of folic acid, which performs many vital cellular functions, including DNA reproduction, cysteine cycle and homocysteine regulation. L-5-Methyltetrahydrofolate calcium is used as in dietary supplements and has been proposed for treatment of cardiovascular disease.

Clinical Use

Folates are a class of water soluble compounds belonging to the Vitamin B complex which are essential for a number of metabolic functions, including processes involved in the development and metabolism of CNS and the production of DNA and RNA, primarily in infancy, adolescence and pregnancy.
Calcium Levomefolate is the active metabolic form of folates in the body.
Folate deficiency consequences can be as serious as birth defects (i.e. "spina bifida"), megaloblastic anaemia, and some types of depression.
Calcium Levomefolate can be the most effective treatment to remedy those deficiencies.
Calcium Levomefolate is formulated in many medical supplements for cases of folate deficiency or need for increased uptake; it is prescribed during pregnancy to prevent birth defects associated with CNS formation and functionality.
It is also the active ingredient in medicinal products prescribed for certain types of depression, disturbed behaviour and Mild Cognitive Impairment (MCI)

Side Effects

Signs of a Levomefolate Calcium allergy: Skin rash Trouble breathing Swelling of the throat, lips, or face Wheezing Runny nose Itchy, watery eyes.
Anaphylaxis is a rare but life-threatening allergic reaction. Signs of anaphylaxis include: Tightening of the throat and airways Nausea Abdominal pain Vomiting Diarrhea Dizziness or lightheadedness Rapid or weak heart rate Reduced blood pressure Seizures Fainting