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HomeProduct name listL-Lactide

L-Lactide

Synonym(s):L-Lactide

  • CAS NO.:4511-42-6
  • Empirical Formula: C6H8O4
  • Molecular Weight: 144.13
  • MDL number: MFCD00070594
  • EINECS: 224-832-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 16:21:11
L-Lactide Structural

What is L-Lactide?

Description

L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione) is a cyclic lactone that is derived from lactic acid. It has the molecular formula C3H6O2 and is an essential building block for synthesizing polylactic acid (PLA) plastics, which are widely used in the manufacturing industry.

Chemical properties

White crystal

The Uses of L-Lactide

(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione may be used in the synthesis of optically active terpyridine containing poly(L-lactide)s, polydisperse lactic acid oligomers, bicyclic and tricyclic lactide derivatives.

What are the applications of Application

(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione is a synthesis reagent used for biodegradable copolymers

What are the applications of Application

L-Lactide is a monomer used to produce polylactic acid (PLA), which is a biodegradable thermoplastic that has many uses in the pharmaceutical industry. Additionally, L-Lactide can be used to modify existing drug carriers or create new ones from scratch. As such, the pharmaceutical industry relies heavily on L-Lactide for its versatile applications.

Flammability and Explosibility

Non flammable

Purification Methods

This is the cyclic dilactone of lactic acid. The (±)-cis-racemate has been distilled with b 142o/8mm; the distillate which solidifies gives yellow needles on recrystallisation from EtOH with m 128o, from Et2O with m 129o, or CHCl3 with m 126o , 1720-1740 cm-1. It hydrolyses in cold max H2O. [Carothers et al. J Am Chem Soc 54 772 1932]. A trans-form (probably RS,SR) has been reported which crystallises from Et2O with m 42-43o [Hummel et al. Acta Cryst (Sect B) 38 1679 1982]. The R,R -(+)-lactide has b 150o/2mm and crystallises from Et2O with m 95o , or m 96.5 -97.5o (from CHCl3) or m 97.7o (from EtOAc) and [] D +297o (c 1.2, *C6H6). The S,S-(-)-lactide has b 150o/2.5mm and crystallises from EtOAc with m 98.7o, or m 95o (from CHCl3) or m 96.5-97.5o (from CCl4) and []D -297o (c 1.2, *C6H6). [Toniolo et al. J Org Chem 35 6 1970, Beilstein 19 H 154, 19 I 179, 19 II 176, 19 IV 1927, 19/5 V 10.]

Properties of L-Lactide

Melting point: 92-94 °C(lit.)
Boiling point: 255°C
Density  1.186±0.06 g/cm3(Predicted)
vapor pressure  0.311Pa at 25℃
refractive index  1.4475
storage temp.  2-8°C
solubility  Soluble in chloroform, and methanol. Slightly soluble in benzene.
form  Solid
color  White to Off-White
optical activity [α]20/D 285°, c = 1 in toluene
Water Solubility  16.7g/L at 20℃
Sensitive  Moisture Sensitive
BRN  82124
Stability: Hygroscopic
CAS DataBase Reference 4511-42-6(CAS DataBase Reference)
EPA Substance Registry System 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)- (4511-42-6)

Safety information for L-Lactide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for L-Lactide

InChIKey JJTUDXZGHPGLLC-IMJSIDKUSA-N

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